Publications by authors named "R Chilcote"
Article Synopsis
- The Early Children's Cancer Group (CCG) conducted a trial comparing the COMP and daunomycin-COMP (D-COMP) regimens for treating non-lymphoblastic non-Hodgkin lymphoma in children, to find out if adding daunomycin improved outcomes.
- A total of 404 patients participated, with most assigned to COMP or D-COMP based on their cancer's characteristics; those with advanced disease received D-COMP.
- Results showed similar 10-year event-free survival rates for both regimens, with some toxicities associated with daunomycin, but ultimately, it did not enhance treatment outcomes for patients.
An 8-year-old boy presented with precocious puberty and a mediastinal mass. A computer search showed that this rare presentation is most common with germ cell tumor of the mediastinum in children with Klinefelter syndrome. The tumor was completely resected after preoperative chemotherapy, and the patient is well 2 years after the operation.
View Article and Find Full Text PDFLymphoepithelioma-like carcinoma (LEC), an undifferentiated carcinoma with pronounced lymphocytic infiltration, often is seen in the nasopharynx as well as in other areas. But such primary pulmonary lung neoplasms in children are rare, and we present the first reported case of primary pulmonary LEC in a child.
View Article and Find Full Text PDFPrimary mediastinal large cell lymphoma in children: a report from the Childrens Cancer Group.
Pediatr Pathol Lab Med
April 1996
Malignant lymphomas arising in the mediastinum account for approximately 60% of all mediastinal tumors in children; two-thirds are non-Hodgkin's lymphomas and one-third represent Hodgkin's disease. In contrast to adults, in children mediastinal non-Hodgkin's lymphomas are usually synonymous with lymphoblastic lymphoma, and nonlymphoblastic lymphomas are rare. We describe nine children with primary mediastinal large cell lymphoma who were treated with the Children's Cancer Group protocol CCG-503, a randomized phase III protocol for disseminated nonlymphoblastic lymphoma.
View Article and Find Full Text PDFPurpose: We analyzed the long-term results of a Childrens Cancer Group (CCG) randomized study comparing cyclophosphamide, vincristine, methotrexate, and prednisone (COMP) versus LSA2L2 as treatment for childhood non-Hodgkin's lymphoma. The initial results were previously reported (N Engl J Med 308:559, 1983).
Patients And Methods: A total of 429 patients are reported here, 68 with localized disease and 361 with disseminated disease.