Publications by authors named "R Chikhladze"

This review aimed to elucidate the critical role of fracture hematoma in forensic medicine, with a specific focus on its utility in differentiating antemortem from postmortem fractures. The study seeks to provide a comprehensive synthesis of current knowledge on the subject, highlighting the biological and medico-legal implications of fracture hematoma analysis in forensic investigations. A systematic review of literature was conducted, encompassing various scientific databases including PubMed, Scopus, and Web of Science, focusing on studies published from 2000 to 2024.

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The tumor microenvironment (TME), where cancer cells reside, plays a crucial role in cancer progression and metastasis. It maintains an immunosuppressive state in many tumors and regulates the differentiation of precursor monocytes into M1 (anti-tumor)- and M2 (pro-tumor)-polarized macrophages, and greatly reduces anticancer drug and nanoparticle delivery. As a result, the effectiveness of recently developed chemo- and/or nanotechnology-mediated immune and magnetic nanoparticle hyperthermia (mNPH) therapies is inhibited significantly.

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Aim of the study was to examine the specific morphological changes of brain cortex in fetal alcoholic intoxication model. The latter was performed in male and female animals by substituting water with 15% ethyl alcohol during 1 month period, which was followed by putting pregnant females on alcohol of the same concentration for the duration of the whole period of pregnancy (21 days). 24 experimental and 10 control (intact) animals were subjected to study overall.

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Clinical-morphological aspects of osteochondroma reflect the rate of cancer growth and its prognosis. Verification of bones forms is required to diagnose exostosis. Revealed forms of osteochondroma differ by clinical course which need different surgical approach.

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The Purpose of the research was to study in the experiment morphological particularities of mandible fracture consolidation by osteosynthesis using Kollapan and Retabolil. The experiments were carried out on sexually matured rabbits. In the first series of the experiments (the control group), mandibula bones fracture was prototyped lower, whereas bone fragments were fixed by miniplate.

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