Publications by authors named "R Chianese"
Hepatocellular carcinoma (HCC) is among the most aggressive and lethal human tumors. Many functional studies have demonstrated the role of non-coding RNAs (ncRNA), particularly microRNAs (miRNA), in the regulation of hepatocarcinogenesis driving pathways. MiR-125a-5p (miR-125a) has been consistently reported as an oncosuppressive miRNA, as demonstrated in vivo and in vitro.
View Article and Find Full Text PDFIntroduction: The contribution of Cannabinoid type 1 receptor (CB1) in mitochondrial energy transduction mechanisms and mitochondrial activities awaits deeper investigations. Our study aims to assess the impact of CB1 absence on the mitochondrial compartment in the liver, focusing on both functional aspects and remodeling processes.
Methods: We used CB1 and CB1 male mice.
Article Synopsis
- - The study investigates whether illegal toxic waste discharge can cause a new reproductive condition called morpho-epigenetic pathozoospermia in young men who typically have normal sperm quality.
- - Findings reveal that exposure to environmental contaminants can lead to serious sperm defects and an increase in low-quality circular RNA in the seminal plasma of men living in heavily polluted areas.
- - The research involved semen samples from 160 healthy men, split between those from a contaminated region in Italy ('Land of Fires') and a control group, highlighting significant differences in sperm quality attributed to environmental pollution.
Article Synopsis
- About 25% of people worldwide have non-alcoholic fatty liver disease (NAFLD), but there are no specific medications to treat it currently.
- This study focused on the adiposity-associated receptor GPR75, mainly found in the brain, and its role in reducing fat accumulation in the liver.
- Mice lacking GPR75 were able to control their food intake better on a high-fat diet, which also correlated with human genetic data showing that certain GPR75 variants lower the risk of developing liver fat, highlighting its potential as a target for NAFLD therapy.
Multiple oncogenic alterations contribute to breast cancer development. Metabolic reprogramming, deeply contributing to tumor microenvironment (TME) education, is now widely recognized as a hallmark of cancer. The reverse Warburg effect induces cancer-associated fibroblasts (CAFs) to produce and secrete L-lactate, enhancing malignant characteristics such as neoangiogenesis, metastatic dissemination, and treatment resistance.
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