Publications by authors named "R Charman"
Copper is ubiquitous as a structural material, and as a reagent in (bio)chemical transformations. A vast number of chemical reactions rely on the near-inevitable preference of copper for positive oxidation states to make useful compounds. Here we show this electronic paradigm can be subverted in a stable compound with a copper-magnesium bond, which conforms to the formal oxidation state of Cu(-I).
View Article and Find Full Text PDFThe intricate σ and π-bonding of N-heterocyclic carbenes (NHCs) to metals and the need to quantify their electronic properties to rationalize reactivity of complexes have resulted in the creation of numerous methodologies to understand the NHC-metal interaction which are, as we now show, flawed. Our search for a unified, easily accessible system to gauge these fundamental properties has resulted in the discovery of two systems that highlight the flaws present in existing systems and provide a more accurate measure of the NHC ligand electronic properties.
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- Organogermane and organostannane compounds play a crucial role in cross coupling reactions, and copper(I) complexes help in accessing these valuable reagents.
- This review explores the chemistry of copper(I) germanide and stannanide complexes, noting their structural characteristics and how they compare to silanide compounds.
- Key differences include the way germanides and stannanides can produce organotetranes from their tetranes, with catalytic reactions being more successful for germanium, while triphenylstannanides uniquely yield phenyl anions, a process not found in silicon or germanium.
A process for the catalytic reduction of nitrous oxide using NHC-ligated copper(I) tert-butoxide precatalysts and Bpin as the reductant is reported. These reactions proceed under mild conditions via copper(I)-boryl intermediates which react with NO by facile O-atom insertion into the Cu-B bond and liberate N. Turnover numbers >800 can be achieved at 80 °C under 1 bar NO.
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- * Researchers developed a strategy targeting bacterial nucleotide excision repair (NER) and screened ~120,000 compounds to identify potential antimicrobial sensitizers, leading to the discovery of Bemcentinib (R428) as a promising candidate.
- * Bemcentinib inhibits the NER protein UvrA's ATPase activity and DNA binding, effectively reducing its DNA repair capabilities, and shows significant growth inhibition of E. coli when combined with DNA-damaging agents like cisplatin, suggesting its potential as an adjuvant in cancer therapy.