Publications by authors named "R Chaix"

Article Synopsis
  • Understanding the deep brain's architecture is difficult due to its complex structure, which controls movement and behavior, and lacks dedicated exploration tools.
  • A new deep-brain MRI architecture atlas was created using advanced MRI-based mapping techniques, featuring a young male adult template and various MRI datasets.
  • This open-source tool includes high-resolution images of 118 labeled deep brain structures, enhancing existing 3D atlases and clinical resources for better analysis.
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Background And Objective: The common structural interpretation of diffusion color-encoded (DCE) maps assumes that the brain is aligned with the gradients of the MRI machine. This is seldom achieved in the field, leading to incorrect red (R), green (G) and blue (B) DCE values for the expected orientation of fiber bundles. We studied the virtual reorientation of gradients according to the anterior commissure - posterior commissure (ACPC) system on the RGB derivatives.

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Human populations harbor a high concentration of deleterious genetic variants. Here, we tested the hypothesis that non-random mating practices affect the distribution of these variants, through exposure in the homozygous state, leading to their purging from the population gene pool. To do so, we produced whole-genome sequencing data for two pairs of Asian populations exhibiting different alliance rules and rates of inbreeding, but with similar effective population sizes.

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Studies have found a pronounced decline in male effective population sizes worldwide around 3000-5000 years ago. This bottleneck was not observed for female effective population sizes, which continued to increase over time. Until now, this remarkable genetic pattern was interpreted as the result of an ancient structuring of human populations into patrilineal groups (gathering closely related males) violently competing with each other.

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