Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism.

A key step in drug discovery, common to many disease areas, is preclinical demonstration of efficacy in a mouse model of disease. However, this demonstration and its translation to the clinic can be impeded by mouse-specific pathways of drug metabolism. Here, we show that a mouse line extensively humanized for the cytochrome P450 gene superfamily ("8HUM") can circumvent these problems.

Characterization of an energy efficient pulsed current TIG welding process on AISI 316 and 304 stainless steels.

This paper presents the characterization of a TIG welding process carried out by means of an arc welding power supply able to provide dc or pulsed current. The arc welding power supply is based on resonant power converters and an FPGA-based control circuit. Dc and multiple pulsed operations up to 1 kHz with different pulse widths have been tested.

Oncological and functional outcomes of transoral laser surgery for hypopharyngeal carcinoma.

Background: Surgical resection or radiotherapy (RT) are standard approaches for early-staged hypopharyngeal squamous cell carcinoma (HPSCC). Transoral laser microsurgery (TOLMS) seems to provide good oncological and functional results with few local complications. The aim of our study was to analyze the outcomes of TOLMS, with or without neck dissection or RT, in the treatment of HPSCC in a tertiary referral center.

Management options for orbital complications of acute rhinosinusitis in pediatric patients.

Objectives: Acute bacterial rhinosinusitis (ABRS) is a common pediatric condition. Despite its tendency to heal without complications, orbital complications (OC) are seen in 6% of patients and can cause vision impairment and put life at risk. Current treatment of this complications involves systemic antibiotics with or without surgical drainage, remaining controversial the use of corticosteroids.