Performance of the Edwards Sapien 3 bioprosthesis in atrioventricular valve position: a case series.

Background: The Edwards Sapien percutaneous valve (Edwards Lifesciences, Irvine, CA, USA) is a promising therapeutic option for congenital atrioventricular disease mostly because of the possibility to accommodate somatic growth with balloon dilatation.

Case Summary: This article reports the performance of the Edwards Sapien 3 valve in atrioventricular valve position in four paediatric patients.

Discussion: Despite aggressive antiplatelet and anticoagulation strategies, most patients showed early bioprosthesis dysfunction, with increasing gradient not related with somatic growth.

Antimicrobial Activity of (Cavs.) Pers. Ethanolic and Aqueous Leaf Extract on the Growth and Biofilm Formation of Selected Bacterial Isolates.

Background: (Aunasin) is an endemic Philippine plant of the family Primulaceae, with several studies showing the genus Ardisia as having potential antibacterial, antiangiogenic, cytotoxic, and antipyretic properties.

Objective: This study aims to determine the antibacterial and antibiofilm-forming activity of ethanolic and aqueous extracts on , Methicillin-Sensitive (MSSA), and Methicillin-Resistant (MRSA).

Methods: This is an experimental study testing the activity against bacterial strains of , MSSA, and MRSA using ethanolic and aqueous extracts of leaves.

Kappa-opioid receptor antagonism in the nucleus accumbens shell distinguishes escalated alcohol consumption and negative affective-like behavior from physiological withdrawal in alcohol-dependence.

Alcohol use disorder (AUD) is a chronic relapsing disease that is deleterious at individual, familial, and societal levels. Although AUD is one of the highest preventable causes of death in the USA, therapies for the treatment of AUD are not sufficient given the heterogeneity of the disorder and the limited number of approved medications. To provide better pharmacological strategies, it is important to understand the neurological underpinnings of AUD.

Short- and long-term survival of children treated with ventricular assist devices in Spain, based on 15 years' experience.

Objectives: To describe the use of ventricular assist devices (VAD) in children in Spain and to identify variables related to survival.

Methods: This is an observational cohort study of all children younger than 18 years of age who underwent an initial implantation of a VAD at any of the 6 paediatric heart transplant centres from May 2006 to December 2020. Subjects were identified retrospectively from each hospital's database.