Publications by authors named "R Carruthers"
Cesarian sections in women with multiple sclerosis: A Canadian prospective pregnancy study.
Mult Scler J Exp Transl Clin
October 2024
Article Synopsis
- * The CANPREG-MS study found that 37.1% of wMS delivered via C-section, which is significantly higher than the 28% rate in the general Canadian population, with many C-sections being unplanned and conducted for obstetrical reasons.
- * There were few instances of MS relapses shortly after delivery, indicating that pregnancies in well-managed wMS do not significantly complicate delivery, providing valuable insights for healthcare providers.
Background: Radical radiotherapy for muscle-invasive bladder cancer (MIBC) is challenging due to large variations in bladder shape, size and volume during treatment, with drinking protocols often employed to mitigate geometric uncertainties. Utilising adaptive radiotherapy together with CBCT imaging to select a treatment plan that best fits the bladder target and reduce normal tissue irradiation is an attractive option to compensate for anatomical changes. The aim of this retrospective study was to compare a bladder empty (BE) protocol to a bladder filling (BF) protocol with regards to variations in target volumes, plan of the day (PoD) selection and plan dosimetry throughout treatment.
View Article and Find Full Text PDFAdult brain tumour research in 2024: Status, challenges and recommendations.
Neuropathol Appl Neurobiol
April 2024
Article Synopsis
- In 2015, patient and charity activism led to the formation of a UK government group focused on brain tumor research.
- By 2018, this resulted in a commitment of £20m from the government and £25m from Cancer Research UK for neuro-oncology over five years.
- The review covers changes in the UK's brain tumor research landscape, identifies seven key research priorities, three overarching themes, and discusses the current status and challenges in this field.
Importance: Biomarkers distinguishing nonrelapsing progressive disease biology from relapsing biology in multiple sclerosis (MS) are lacking. Cerebrospinal fluid (CSF) is an accessible fluid that most closely reflects central nervous system biology.
Objective: To identify CSF biological measures associated with progressive MS pathobiology.
Introduction: To protect citizens during the COVID-19 pandemic unprecedented public health restrictions were imposed on everyday life in the UK and around the world. In emergencies like COVID-19, it is crucial for policymakers to be able to gauge the public response and sentiment to such measures in almost real-time and establish best practices for the use of social media for emergency response.
Methods: In this study, we explored Twitter as a data source for assessing public reaction to the pandemic.