Publications by authors named "R Cardigan"
Background: Early resuscitation is based on platelet-poor components such as red blood cells and plasma (RBC + P), contributing to platelet dilution and worsening of trauma-induced coagulopathy (TIC). We aimed to compare the ability of cold-stored whole blood (WB) versus RBC + P as a single component to correct TIC.
Study Design And Methods: Blood samples were collected on admission from trauma patients who required activation of the major hemorrhage protocol at a single UK major trauma center in 2021/2022.
Background: Metrics evaluating the functional quality of red blood cells (RBCs) must consider their role in oxygen delivery. Whereas oxygen-carrying capacity is routinely reported using haemoglobin assays, the rate of oxygen exchange is not measured, yet also important for tissue oxygenation. Since oxygen-unloading depends on the diffusion pathlength inside RBCs, cell geometry offers a plausible surrogate.
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- - The study explores the potential benefits of universal plasma for hospitals in England, highlighting its safety as a major advantage but also identifying cost as a significant barrier to its adoption.
- - Surveys distributed to hospitals revealed that many respondents were willing to pay more for universal plasma, with 95% indicating they would consider integrating it into their stock, expecting reduced plasma wastage of up to 25%.
- - Hospitals recognized that universal plasma could facilitate quicker access to transfusions, particularly in emergency situations, with 56% believing it would greatly benefit trauma departments.
Article Synopsis
- Blood donations were screened for high-titre anti-A/B antibodies to minimize the risk of transfusion reactions, focusing on data from Australia and England between 2018-2021.
- Analysis of nearly 6 million donations showed that females, younger donors, and those from certain ethnic backgrounds were more likely to test HT-positive, with a significantly higher rate in Australia compared to England.
- The study concluded that factors like sex, age, ABO blood group, and ethnicity influence HT-positive rates, while differences in testing methods contributed to the variations observed between the two countries.
Background: Early blood transfusion improves survival in patients with life-threatening bleeding, but the optimal transfusion strategy in the pre-hospital setting has yet to be established. Although there is some evidence of benefit with the use of whole blood, there have been no randomised controlled trials exploring the clinical and cost effectiveness of pre-hospital administration of whole blood versus component therapy for trauma patients with life-threatening bleeding. The aim of this trial is to determine whether pre-hospital leukocyte-depleted whole blood transfusion is better than standard care (blood component transfusion) in reducing the proportion of participants who experience death or massive transfusion at 24 h.
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