Publications by authors named "R Cantello"
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that primarily affects the motor neurons in the brain and spinal cord. While the exact cause of ALS is not fully understood, a combination of genetic and environmental factors is believed to contribute to its development. Growth arrest-specific 6 (Gas6), a vitamin K-dependent protein, has been recognized to enhance oligodendrocytes and neurons' survival and is associated with different kinds of (neuro)inflammatory conditions.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the roles of the protein growth arrest-specific 6 (Gas6) and its receptors (TAM) in multiple sclerosis (MS), focusing on their levels in cerebrospinal fluid (CSF) and serum during diagnosis and their correlation with disease severity.
- - A total of 64 MS patients were assessed based on diagnostic criteria, with samples collected pre-treatment to analyze clinical data and levels of Gas6 and TAM proteins using ELISA, comparing them to neurofilament levels as disability biomarkers.
- - Results showed that higher levels of serum sAxl and CSF Gas6 were linked to lower disability scores (EDSS) at diagnosis, while serum Gas6 correlated with lower MS severity scores (MSS
Background: Neurofilament light chains (NfL) are cytoskeletal biomarkers of axonal damage, about 40-fold higher in cerebrospinal fluid (CSF) compared to serum, and requiring ultrasensitive techniques to be measured in this latter fluid.
Objectives: To compare CSF and serum NfL levels in multiple sclerosis (MS) patients using different platforms.
Methods: 60 newly diagnosed relapsing-remitting MS patients (38 females; median age: 36.
Mutations in the 43 kDa transactive-response (TAR)-DNA-binding protein () are associated with 2-5% of familial Amyotrophic Lateral Sclerosis (ALS) cases. TAR DNA-Binding Protein 43 (TDP-43) is an RNA/DNA-binding protein involved in several cellular mechanisms (e.g.
View Article and Find Full Text PDF