Publications by authors named "R Cannon"
Background: Recurrent spontaneous abortion (RSA) is intricately linked to metabolic dysregulation at the maternal-fetal interface during early gestation. Abnormal levels of essential fatty acids and downstream oxylipins in decidua and chorionic villi have been identified as potential risk factors for RSA. Oxylipins have been linked to excessive inflammation, which might disrupt maternal-fetal immune tolerance, potentially contributing to RSA.
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- Women with inflammatory bowel disease (IBD) face challenges in reproductive health, with many not receiving adequate contraception counseling despite a high comfort level in discussing these issues with their healthcare providers.
- A study of 338 women revealed that while 74% used contraception, long-acting methods were relatively underutilized, especially among those in remission, indicating a need for improved education on contraceptive options.
- Key preferences for contraceptive methods included effectiveness, ease of use, and minimal side effects, emphasizing the importance of better communication and support from healthcare professionals in managing reproductive health for women with IBD.
Background: Diphtheria is a recurrent threat with endemic still occurs in many parts of the world. The standard of care is horse serum-derived diphtheria antitoxin (eDAT), which is in critical short supply globally. S315 is a fully human, monoclonal immunoglobulin G1 neutralizing antibody, specific to the receptor-binding domain of diphtheria toxin.
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