Trigeminal nerve microstructure is linked with neuroinflammation and brainstem activity in migraine.

Although the pathophysiology of migraine involves a complex ensemble of peripheral and central nervous system changes that remain incompletely understood, the activation and sensitization of the trigeminovascular system is believed to play a major role. However, non-invasive, in vivo neuroimaging studies investigating the underlying neural mechanisms of trigeminal system abnormalities in human migraine patients are limited. Here, we studied 60 patients with migraine (55 females, mean age ± SD: 36.

FEV1/FEV6 Cutoff Points to Avoid False Negatives When Using Portable Devices, PICO-6 and COPD-6, in COPD Detection in Primary Healthcare Services.

: Chronic obstructive pulmonary disease (COPD) is a frequent but underdiagnosed disease, primarily due to the lack of access to forced spirometry (FS) in primary care. Portable, easy-to-use expiratory flow meters like Piko-6 and COPD-6 that measure FEV, FEV, and FEV/FEV ratio provide an alternative. Given that Piko-6 and COPD-6 devices measure FEV but not FVC, the aim of the study is to determine the optimal cutoff value for the FEV/FEV ratio of each device to avoid false negatives when these devices are used for COPD screening in primary care (PC).

Nanotechnological Plastic Flooring: Implications for Broiler Chicken Performance, Health, and Carcass Quality.

This study evaluated the effects of two types of plastic flooring-one with and one without nanotechnological antimicrobial additives-used as complete or partial replacements for wood shavings on broiler chicken performance, yield, meat quality, and litter microbiology over 42 days. A total of 1500 Ross 408 male broiler chicks were randomly assigned to five treatment groups: wood shavings (WS), plastic flooring (PF), a 50/50 mix of plastic flooring and wood shavings (PF + WS), plastic flooring with antimicrobial additives (PFA), and a 50/50 mix of antimicrobial plastic flooring and wood shavings (PFA + WS). This study evaluated organ biometrics (liver, heart, spleen, and gizzard), the severity of lesions, microbiological profiles, performance indices, and meat quality.

Markedly T2-Hypointense Clival Plasmacytoma With Light Chain Deposition Disease: A Case Report.

Plasmacytomas are rare monoclonal neoplastic plasma cell proliferations in soft tissue or bone, with clival plasmacytomas being extremely rare and occasionally presenting with light chain deposition disease (LCDD). While imaging findings for clival plasmacytomas have shown variable T2 signal characteristics, complete T2 signal loss has not been previously reported. We present a case of a 61-year-old female found to have a 1.