Publications by authors named "R Calvo"
Celiac plexus (CP) block (CPB) and neurolysis (CPN) are interventional techniques employed in human analgesia to control visceral pain originating from the upper abdomen. Visceral pain is common in animals and its treatment is challenging. A percutaneous ultrasound (US)-guided approach to the CP has been reported in people but not in veterinary species.
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- - Recent analyses suggest that the brain operates at a critical point of instability, using data from many neurons but often overlook detailed timing in brain activity measurements.
- - A new framework is introduced to better analyze brain activity, focusing on different frequency bands and using spatiotemporal patterns for a more detailed understanding.
- - When applied to a study comparing healthy individuals and those with Parkinson's disease, this framework reveals important differences in brain activity patterns and criticality, showcasing its potential benefits in neuroresearch.
TNFα-inhibitors cycling with golimumab as second drug in inflammatory arthritis patients: Data from the multicenter GO-REAL registry.
Reumatol Clin (Engl Ed)
December 2024
Article Synopsis
- This study evaluated the effectiveness and persistence of golimumab (GLM) in patients with rheumatoid arthritis, axial spondyloarthritis, and psoriatic arthritis who previously used other TNF inhibitors compared to those who haven't.
- A total of 192 patients were included, with follow-up results indicating that the majority discontinued GLM due to inefficacy, and the median survival for GLM treatment was similar for both experienced and naive patients.
- The study concluded that prior TNFi experience did not significantly affect the survival or persistence of GLM treatment, but having public health insurance was linked to higher discontinuation rates.
Purpose: The rise of frail patients in the worldwide population poses a challenge in the prostate cancer surgical care. In this light, we aimed to compare perioperative and early surgical outcomes of Extraperitoneal Single Port (SP)- vs Transperitoneal Multiport (MP) - Robot Assisted Radical Prostatectomy (RALP) in different frailty settings.
Materials And Methods: Clinical and surgical data of all consecutive patients treated with RALP between March 2014 and October 2023 were gathered.
Article Synopsis
- * Researchers developed high-throughput assays to find compounds that correct severe misfolding of the pathogenic L444P-variant of GCase, screening over 10,000 compounds and identifying multiple stabilizers.
- * The study demonstrated that a specific compound, NCGC326, not only improved GCase levels but also worked well in combination with other treatments, suggesting potential for enhanced therapeutic approaches.