Publications by authors named "R Caldarella"
Studying models of healthy aging and exceptional longevity is crucial to understanding a possible longevity signature, as most show resistance to age-related diseases. In particular, semi- and supercentenarians are a highly selected group, having survived significant adversities, including the Spanish flu and COVID-19 pandemics, indicating distinctive immune system characteristics. This paper analyzes the inflammatory scores (INFLA-score, Systemic Inflammation Response Index (SIRI)) and Aging-Related Immune Phenotype (ARIP) indicators calculated from the dataset of the DESIGN project, including 249 participants aged 19-111 years, aiming to understand the immune-inflammatory (IMFLAM) role in achieving longevity.
View Article and Find Full Text PDFChrono-nutritional factors may play a significant role in glucose regulation and the risk of type 2 diabetes (T2D). We investigated the association between breakfast skipping (BS) and fasting plasma glucose (FPG) levels in a non-diabetic cohort of the ABCD project (nutrition, cardiovascular wellness and diabetes) representing the general population of Palermo, Italy Among the 623 participants included in the analysis, 118 individuals were identified as BS. In men, BS was associated with higher values of FPG ( < .
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- Lipoprotein(a) [Lp(a)] is identified as a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), with this study focusing on its levels among patients with different genetic dyslipidemias and the general population.
- The research involved various cohorts including hypercholesterolemic patients and free-living subjects, revealing that those with familial hypercholesterolemia (FH) had notably higher median Lp(a) levels compared to those with familial hypobetalipoproteinemia type 1 (FHBL1) and the general population.
- It was found that individuals at high cardiovascular (CV) risk have significantly elevated Lp(a) levels, suggesting that assessing Lp(a) in conjunction with
Article Synopsis
- Multiple sclerosis (MS) is an autoimmune disease that causes damage to the nervous system, and the effects of high-intensity interval training (HIIT) on MS patients were investigated in this study.
- 16 MS patients completed an 8-week HIIT program, which was conducted remotely and compared against a control group that did not exercise.
- Results showed significant improvements in neuromotor abilities, bone formation markers, and lipid profiles, indicating that HIIT can enhance physical function and overall health in MS patients.
Article Synopsis
- - This study examined how energy intake (EI) and insulin resistance contribute to weight changes in a group of 707 adults over four years, focusing on the influence of diet and genetic factors.
- - Out of the participants, 87 gained weight (5 kg or more) while 620 did not; weight gainers displayed higher energy intake and insulin resistance compared to non-gainers, despite similar initial characteristics.
- - The findings suggest that increased energy intake correlates with weight gain, and specific genetic factors, like variations in the PNPLA3 gene, may play a role in this energy balance and resulting insulin resistance.