Publications by authors named "R CARRON"
Background: Vagus nerve stimulation (VNS) is an established surgical option for neuromodulation. Lead failure is a significant complication mainly reported in children.
Methods: We conducted a retrospective review of all VNS-related surgeries for refractory epilepsy in adults performed by a single experienced surgeon at a French national referral center from November 2011 to March 2023.
Objective: This study aims to evaluate the efficacy and safety of deep brain stimulation (DBS) of the medial pulvinar nucleus (PuM) in reducing seizure frequency and addressing comorbidities in patients with drug and vagal nerve-resistant focal epilepsy.
Methods: This is an open-label prospective treatment trial with a planned enrollment of 12 patients suffering from medically refractory epilepsy (Clinical trial gov NCT04692701), for which the interim 12-month post-implantation results for the first 6 patients are being reported. Inclusion criteria were focal epilepsy not suitable for or after failed surgical intervention and previous failure of neurostimulation therapies (vagus nerve stimulation or anterior thalamic nucleus DBS).
Medication refractory focal epilepsy creates a significant challenge, with approximately 30% of patients ineligible for surgery due to the involvement of eloquent cortex in the epileptogenic network. For such patients with limited surgical options, electrical neuromodulation represents a promising alternative therapy. In this study, we investigate the potential of non-invasive temporal interference (TI) electrical stimulation to reduce epileptic biomarkers in patients with epilepsy by comparing intracerebral recordings obtained before, during, and after TI stimulation, to recordings during low and high kHz frequency (HF) sham stimulation.
View Article and Find Full Text PDFPeriventricular nodular heterotopia (PVNH) is a neuronal migration disorder often associated with drug-resistant epilepsy. The epileptogenic zone network (EZN) in PVNH is generally large, contraindicating surgery. Stereoelectroencephalography (SEEG) can be proposed to map the EZN and perform radiofrequency thermocoagulation (THC) with an efficacy rate of approximately 65%.
View Article and Find Full Text PDFArticle Synopsis
- The study examines how providing contextual information impacts moral judgment and decision-making in sacrificial dilemmas.
- Participants (334 total) were divided into two groups: one received detailed scenarios, while the other received no context before making moral decisions.
- Results showed that while moral judgments remained unchanged, the presence of scenarios increased utilitarian choices, suggesting context can influence perceived action plausibility without affecting emotional responses.
- The findings highlight the importance of contextual factors in understanding moral dilemmas.