Publications by authors named "R C Wiggins"
Background And Objectives: Vestibular schwannomas demonstrate different responses after stereotactic radiosurgery (SRS), commonly including a transient loss of internal enhancement on postcontrast T1-weighted MRI thought to be due to an early reduction in tumor vascularity. We used dynamic contrast-enhanced based golden-angle radial sparse parallel (GRASP) MRI to characterize the vascular permeability changes underlying this phenomenon, with correlations to long-term tumor regression.
Methods: Consecutive patients with vestibular schwannoma who underwent SRS between 2017 and 2019, had a transient loss of enhancement after SRS, and had long-term longitudinal GRASP studies (6, 18, and 30 months) were included in this retrospective cohort analysis (n = 19).
Article Synopsis
- Niclosamide shows promise as a cancer treatment due to its ability to inhibit multiple cancer pathways, but poor bioavailability limits its clinical use.
- Research is exploring ways to enhance niclosamide bioavailability, including chemical modifications and innovative nanotechnology delivery methods.
- Potential strategies include creating more soluble niclosamide derivatives and investigating the role of metabolism and enzymatic inhibition to strengthen drug efficacy and targeting in cancer therapy.
Article Synopsis
- A phase 2a clinical trial demonstrated that the leishmaniasis vaccine ChAd63-KH is safe and can generate an immune response in Sudanese patients with post kala-azar dermal leishmaniasis (PKDL).
- A follow-up phase 2b randomized trial assessed its therapeutic efficacy, comparing the vaccine to a placebo in 86 participants with uncomplicated PKDL.
- Results indicated no significant improvement in clinical outcomes or severity of PKDL, suggesting that ChAd63-KH does not provide therapeutic benefits for this condition in the studied population.