Publications by authors named "R C Tustin"
Article Synopsis
- * A study involving 88 critically ill pediatric patients identified three immune subphenotypes linked to clinical outcomes, indicating meaningful differences in immune dysregulation between patients with and without sepsis.
- * The research highlighted the role of STAT3 hyperactivation in lymphocytes, particularly in the sickest subgroup of patients, suggesting that targeting this dysregulated pathway could improve treatment for severe cases of multiple organ dysfunction syndrome (MODS).
Article Synopsis
- The text discusses the traditional treatment approach for synchronous prostate and bladder cancers, which typically involves radical cystoprostatectomy and may include chemotherapy, but notes a lack of reports on curative chemoradiation therapy.
- It presents a unique case of a 70-year-old man with both small cell and urothelial carcinoma in the bladder and adenocarcinoma in the prostate, who achieved long-term survival after receiving concurrent chemoradiotherapy.
- The case suggests that definitive chemoradiation therapy is a viable and effective option for organ preservation in patients with localized synchronous prostate and bladder cancers, with minimal side effects.
Host biomarker testing can be used as an adjunct to the clinical assessment of patients with infections and might be particularly impactful in resource-constrained settings. Research on the merits of this approach at peripheral levels of low- and middle-income country health systems is limited. In part, this is due to resource-intense requirements for sample collection, processing, and storage.
View Article and Find Full Text PDFImmunotherapy-related gastritis: Two case reports and literature review.
Clin Med Insights Oncol
July 2021
Immunotherapy is increasingly defining a role in a wide variety of tumours such that as use becomes more ubiquitous, so too will the complications. A relatively rare complication of immunotherapy use is immune-related gastritis. In this case series, we present two cases of immunotherapy-related gastritis from our institution and undertake a comprehensive review and analysis of the literature around this less common adverse event.
View Article and Find Full Text PDFAntibody-like molecules were evaluated with potent simian immunodeficiency virus (SIV) neutralizing properties (immunoadhesins) that were delivered by a recombinant adeno-associated virus (rAAV) vector in the SIV-infected rhesus macaque model. When injected intramuscularly into the host, the vector directs production of the transgenes with antibody-like binding properties that lead to serum neutralizing activity against SIV. To extend the half-life of the immunoadhesins, rhesus cluster of differentiation 4 (CD4) and a single-chain antibody (4L6) were fused with albumin molecules, and these constructs were tested in our model of SIV infection.
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