Adult withdrawal of long-term Benzophenone-3 treatment induces regression of mammary ductal branching in a diet-dependent manner.

Benzophenone-3 (also referred to as oxybenzone) is a putative endocrine disrupting chemical and common ingredient in sunscreens and other personal care products. We previously showed that benzophenone-3 can have both promotional and protective effects on mammary tumorigenesis dependent upon dietary fat. The current study examined diet-dependent effects of benzophenone-3 in mammary ductal development in BALB/c mice.

Evidence update on e-cigarette dependence: A systematic review and meta-analysis.

Introduction: We conducted this review to examine the risk of e-cigarette dependence in different populations by updating the review on this topic by the National Academies of Science, Engineering, and Medicine.

Methods: Six academic databases were searched for studies published between September 2017 and December 2023. We included peer-reviewed human, animal, cell/in vitro original studies examining associations of e-cigarette use and dependence but excluded qualitative studies.

Priming versus propagating: distinct immune effects of an alpha- versus beta-particle emitting radiopharmaceutical when combined with immune checkpoint inhibition.

Radiopharmaceutical therapy (RPT) enhances tumor response to immune checkpoint inhibitors (ICI) in preclinical models, but the effects of different radioisotopes have not been thoroughly compared. To evaluate mechanisms of response to RPT+ICI, we used NM600, an alkylphosphocholine selectively taken up by most tumors. Effects of Y-, Lu-, and Ac-NM600 + ICIs were compared in syngeneic murine models, B78 melanoma (poorly immunogenic) and MC38 colorectal cancer (immunogenic).

Computationally reconstructing the evolution of cancer progression risk.

Understanding the evolution of cancer in its early stages is critical to identifying key drivers of cancer progression and developing better early diagnostics or prophylactic treatments. Early cancer is difficult to observe, though, since it is generally asymptomatic until extensive genetic damage has accumulated. In this study, we develop a computational approach to infer how once-healthy cells enter into and become committed to a pathway of aggressive cancer.

Broadening the conceptualization of panic disorder to include the fear presentation of avoidant/restrictive food intake disorder: The legacy of panic control therapy.

The presentation of avoidant/restrictive food intake disorder (ARFID) characterized by fear of aversive consequences of eating (fear-ARFID) has both phenomenological and mechanistic similarities to panic disorder. In this narrative review, we propose a shared model of the pathogenesis of the two disorders, centered on interoceptive sensitivity as the key maintenance mechanism. We review the evidence that fear-ARFID, which involves restrictive eating motivated by a desire to avoid aversive events (e.