Developing Topics.

Background: 20-hydroxyeicosatetranoic acid (20-HETE) is a potent vasoconstrictor synthesized by the CYP4F2 enzyme. The CYP4F2 missense variant rs3093105 A>C (W12G) has been implicated in hypertension and stroke, risk factors for Alzheimer's disease (AD), and with decreased 20-HETE activity. To explore the potential role of the CYP4F2/20-HETE pathway and AD, this study investigated associations between the rs3093105 variant and AD phenotypes.

Malaysia outbreak survivors retain detectable Nipah antibodies and memory B cells after 25 years.

Objective: To evaluate the long-term humoral immune response to Nipah virus (NiV) in a cohort of 25 survivors after 25 years of post-infection.

Methods: A total of 25 survivors of NiV infection from the 1998 outbreak were recruited for sample collection. The serum IgG antibody response to NiV antigens, specifically nucleocapsid (N), fusion glycoprotein (F) and attachment glycoprotein (G) was evaluated using ELISA.

CAECENET: An automatic system processing photometer and ceilometer data from different networks to provide columnar and vertically-resolved aerosol properties.

This work introduces CAECENET, a new system capable of automatically retrieving columnar and vertically-resolved aerosol properties running the GRASP (Generalized Retrieval of Atmosphere and Surface Properties) algorithm using sun-sky photometer (aerosol optical depth, AOD; and sky radiance measurements) and ceilometer (range corrected signal; RCS) data as input. This method, so called GRASPpac, is implemented in CAECENET, which assimilates sun-sky photometers data from CÆLIS database and ceilometer data from ICENET database (Iberian Ceilometer Network). CAECENET allows for continuous and near-real-time monitoring of both vertical and columnar aerosol properties.

Defining quality categories for evaluation of the doctor-patient relationship assessed through the patient-doctor relationship questionnaire (PDRQ-9).

Background: The quality of the doctor-patient relationship plays a crucial role in patients' experiences with healthcare services, positively influencing clinical outcomes and satisfaction with care. The Patient-Doctor Relationship Questionnaire (PDRQ-9) is widely used to assess this relationship. However, there are no quality categories that can be derived from the instrument's score to facilitate understanding and decision-making.