PepGAT, a chitinase-derived peptide, alters the proteomic profile of colorectal cancer cells and perturbs pathways involved in cancer survival.

Colorectal cancer (CRC) affects the population worldwide, occupying the first place in terms of death and incidence. Synthetic peptides (SPs) emerged as alternative molecules due to their activity and low toxicity. Proteomic analysis of PepGAT-treated HCT-116 cells revealed a decreased abundance of proteins involved in ROS metabolism and energetic metabolisms, cell cycle, DNA repair, migration, invasion, cancer aggressiveness, and proteins involved in resistance to 5-FU.

Inhibitory Effect on the Tyrosinase Activity and Low Cytotoxicity of Monounsaturated Long-Chain Chelating Fatty Ester.

In the present study, 5-Hydroxy-2-(Oleoyloxymethyl) -4H-pyran-4-one (KMO 3), and their chelated with Cu(II) and Fe(III) ions were synthesized to explore their inhibitory activity against tyrosinase and cytotoxicity. To this end, the structures of the obtained compounds were confirmed by ATR/FT-IR, 13C and 1H-NMR, and UV-vis techniques. The results show that chelating fatty ester presents the bands at 1567m, 1511w cm-1 attributed to the coordinated carbonyl (Cu(II)←[O=C]2), and the bands at 1540m, 1519m cm-1 which were attributed to the coordinated carbonyl (Fe(III)←[O=C]3).

Manufacturing sulfated cellulose nanofibers using a unique combined DES-based pretreatment-functionalization protocol for metal ion decontamination through porous adsorbents.

This study confirms the efficacy of a unique combined pretreatment-functionalization protocol based on the use of deep eutectic solvent (DES) to obtain sulfated lignocellulose and cellulose nanofibers (SLNF or SNF) hydrogels, which have been successfully shaped as sponge-based adsorbents and fruitfully assessed for the removal of heavy metals from water. A comprehensive characterization study was conducted, demonstrating an excellent degree of sulfation (0.62) in DES-treated wheat straw-derived nanofibers.

Transcriptome analysis displays new molecular insights into the mechanisms of action of Mebendazole in gastric cancer cells.

Gastric cancer (GC) is a common cancer worldwide. Therefore, searching for effective treatments is essential, and drug repositioning can be a promising strategy to find new potential drugs for GC therapy. For the first time, we sought to identify molecular alterations and validate new mechanisms related to Mebendazole (MBZ) treatment in GC cells through transcriptome analysis using microarray technology.