Publications by authors named "R C Melchers"
Article Synopsis
- Lymphomatoid papulosis (LyP) is a rare skin disorder affecting T-cells, and there's limited information about its impact on children.
- A study analyzed data from 87 pediatric patients diagnosed with LyP over a 24-year period, noting that most cases were initially misdiagnosed and the average age at onset was 7 years.
- The prognosis appears positive, with a 100% overall survival rate, although 10% of patients had associated blood cancers, indicating a significantly higher risk of malignancy compared to the general youth population.
In kidney transplantation, survival rates are still partly impaired due to the deleterious effects of donor specific HLA antibodies (DSA). However, not all luminex-defined DSA appear to be clinically relevant. Further analysis of DSA recognizing polymorphic amino acid configurations, called eplets or functional epitopes, might improve the discrimination between clinically relevant vs.
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- In kidney transplants, donor HLA antibodies increase the risk of graft loss, and the ElliPro score is used to assess donor eplets relevant to these antibodies.
- In a study of a large Dutch kidney transplant group, no significant differences in ElliPro scores were found when comparing early graft failures to long-surviving transplants.
- Ultimately, the research concluded that ElliPro scores are not effective in predicting which donor HLA antibodies may lead to early or late kidney graft loss.
In this study, the corrosion inhibition efficiency of thioridazine hydrochloride (TH), an antipsychotic drug, on mild steel (commonly used pipeline material in the oil and gas industry) in 1 M hydrochloric acid (HCl) was evaluated using electrochemical techniques and weight loss method. Electrochemical impedance spectroscopy (EIS) results suggest that TH significantly enhances the polarization resistance (R) of mild steel. Similarly, potentiodynamic polarization results showed that the corrosion current density (i) of mild steel decreased significantly with addition of TH.
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