Publications by authors named "R C Luciani"
Listening to natural auditory scenes leads to distinct neuronal activity patterns in the early visual cortex (EVC) of blindfolded sighted and congenitally blind participants. This pattern of sound decoding is organized by eccentricity, with the accuracy of auditory information increasing from foveal to far peripheral retinotopic regions in the EVC (V1, V2, and V3). This functional organization by eccentricity is predicted by primate anatomical connectivity, where cortical feedback projections from auditory and other non-visual areas preferentially target the periphery of early visual areas.
View Article and Find Full Text PDFPteridine reductase 1 (PTR1) is a catalytic protein belonging to the folate metabolic pathway in Trypanosmatidic parasites. PTR1 is a known target for the medicinal chemistry development of antiparasitic agents against Trypanosomiasis and Leishmaniasis. In previous studies, new nitro derivatives were elaborated as PTR1 inhibitors.
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- Researchers identified broad-spectrum anti-infective agents from a library of 456 compounds through a high-throughput screening program, focusing on compounds effective against specific parasite species.
- Using machine learning, they characterized and synthesized 44 compounds showing strong antiparasitic properties with minimal toxicity, highlighting one promising lead with a unique chemical structure.
- The study utilized advanced chemoinformatic and machine learning tools to handle complex data, facilitating the selection and optimization of compounds for further biological and toxicological evaluation.
Background: Despite advance in pharmacotherapy of lipid disorders, lipoprotein apheresis (LA) plays a leading role in the management of severe hypercholesterolemia and in atherosclerosis prevention.
Methods: Aim of this study was to retrospectively evaluate Charlson Comorbidity Index (CCI), presence of major comorbidity, and/or concomitant polypharmacy (definite as 5+ drugs daily) in patients with inherited dyslipidemias on chronic LA.
Results: Since 1994, we performed more than 500 LA treatment/year and followed a total of 83 patients (age 56 [47-65] years, male 75%).
Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors induces over-expression of this protein and development of drug resistance. We thus pursued an alternative strategy that led us to the discovery of TS-dimer destabilizers.
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