Background: Racial differences in the prevalence of mild cognitive impairment (MCI) and Alzheimer's Disease and related dementia (ADRD) are well documented in aging populations. Using data from a large longitudinal study of adults, Black-White disparities in mild cognitive impairment (MCI) were estimated and putative mediators of Black-White disparities in cognitive function were examined.
Method: The prevalence of MCI was determined algorithmically for Black and White adults, and longitudinal indicators of income, educational attainment, and interpersonal discrimination were used to conduct a parallel mediation analysis of Black-White disparities in executive function and episodic memory.
Background: Childhood adversity has been associated with increased peripheral inflammation in adulthood. However, not all individuals who experience early adversity develop these inflammatory outcomes. Separately, there is also a link between various internalizing emotional distress conditions (e.
View Article and Find Full Text PDFThe precise control of complex reactions is critical for biological processes, yet our inability to design for specific outcomes limits the development of synthetic analogs. Here, we leverage differentiable simulators to design nontrivial reaction pathways in colloidal assemblies. By optimizing over external structures, we achieve controlled disassembly and particle release from colloidal shells.
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