Publications by authors named "R C Gauthier"
Hydrogels are promising scaffolds for tissue regeneration, and borosilicate glass particles have demonstrated potential in enhancing the biological behaviour of dental pulp cells. However, the specific morphological characteristics of dental lesions and the diverse requirements of dental tissues require biocompatible, bioactive, and shapeable scaffolds. This study aimed to evaluate the in vitro biological behaviour of human gingival fibroblasts (HGFs) in contact with an experimental aluminum-free borosilicate glass-functionalized hydrogel.
View Article and Find Full Text PDFFluorine-19 is an ideal nucleus for studying biological systems using NMR due to its rarity in biological environments and its favorable magnetic properties. In this work, we used a mixture of monofluorinated palmitic acids (PAs) as tracers to investigate the molecular interaction of the fluorinated drug rosuvastatin in model lipid membranes. More specifically, PAs labeled at the fourth and eighth carbon positions of their acyl chains were coincorporated in phospholipid bilayers to probe different depths of the hydrophobic core.
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- The study aimed to create engineered cartilage using pyrocarbon (PyC) biomaterial and differentiated chondrocytes, focusing on a scaffold-free and mechanically stimulated process.
- By applying uniaxial cyclic compression in a specially designed tribo-bioreactor, the researchers aimed to keep the chondrocytes in a cartilage-like phenotype while enhancing the matrix composition.
- Findings indicated that the combination of PyC and dynamic stimulation led to denser constructs with improved mechanical properties and no signs of unwanted cell maturation, highlighting the effectiveness of integrating biomaterials with mechanical stimuli in tissue engineering.
The transformation of crystalline silicon to amorphous silicon during ball milling was quantitatively measured by x-ray diffraction and electrochemical methods. Amorphous silicon was found to form rapidly from the very initial stages of ball milling. Simultaneously, the grain size of the crystalline silicon phase decreased.
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- - Osteocytes play a crucial role in bone mechanobiology by communicating mechanical signals through the interconnected lacunocanalicular network (LCN) filled with interstitial fluid.
- - This study aimed to gather detailed morphological data on the human LCN using advanced imaging techniques, specifically measuring 27 femoral bone samples with a 100 nm voxel size.
- - Results showed variability in canalicular morphology, with some differences between males and females, although only larger canaliculi were detected; this research is groundbreaking as it presents new data for further investigations on LCN permeability.