Lateral abdominal wall hernias after coughing: a single center experience.

Purpose: Forceful coughing is assumed to be an uncommon etiology for lateral abdominal wall hernias. The literature regarding this topic is very limited and there is a lack of consensus in management, both operative and non-operative. We aim to report our center's experience in repair of lateral abdominal wall hernias secondary to vigorous coughing.

Machine learning analysis of the orbitofrontal cortex transcriptome of human opioid users identifies Shisa7 as a translational target relevant for heroin-seeking leveraging a male rat model.

Background: Identifying neurobiological targets predictive of the molecular neuropathophysiological signature of human opioid use disorder (OUD) could expedite new treatments. OUD is characterized by dysregulated cognition and goal-directed behavior mediated by the orbitofrontal cortex (OFC), and next-generation sequencing could provide insights regarding novel targets.

Methods: Here, we used machine learning to evaluate human post-mortem OFC RNA-sequencing datasets from heroin-users and controls to identify transcripts predictive of heroin use.

Low pH Means More Female Offspring: A Multigenerational Plasticity in the Sex Ratio of Marine Bivalves.

Global changes can profoundly affect the sex determination and reproductive output of marine organisms, disrupting the population structure and ecosystems. High COdriven low pH in the context of ocean acidification (OA) has been shown to severely affect various calcifiers, but less is known about the extent to which low pH influences sex determination and reproduction of marine organisms, particularly mollusks. This study is the first to report a biased sex ratio over multiple generations toward females, driven by exposure to high CO-induced low pH environments, using the ecologically and economically important Portuguese oyster () as a model.

Anterior Gastropexy for Paraesophageal Hernia Repair: A Randomized Clinical Trial.

Importance: Paraesophageal hernias can cause severe limitations in quality of life and life-threatening complications. Even though minimally invasive paraesophageal hernia repair (MIS-PEHR) is safe and effective, anatomic recurrence rates remain notoriously high. Retrospective data suggest that suturing the stomach to the anterior abdominal wall after repair-an anterior gastropexy-may reduce recurrence, but this adjunct is currently not the standard of care.

Trauma-related moderators of associations between sex hormones and PTSD symptoms: a replication-extension.

Post-traumatic stress disorder (PTSD) disproportionately affects women and recent evidence suggests that unique associations between sex hormones (e.g. estradiol and progesterone) and PTSD symptoms may contribute to this difference.