Publications by authors named "R C Eberle"

Article Synopsis
  • The study investigates the use of electroretinography (ERG) as a potential measure of neurodegeneration in people with multiple sclerosis (pwMS) with more advanced disease.
  • Delays in ERG peak times were found in pwMS regardless of previous optic neuritis, indicating common bipolar dysfunction, but no influence from EDSS scores or disease status was observed.
  • While ERG shows abnormal findings in pwMS with moderate to severe disability, it may not be effective for monitoring disease progression or prognosis.
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Over a century has passed since Alois Alzheimer first described Alzheimer's disease (AD), and since then, researchers have made significant strides in understanding its pathology. One key feature of AD is the presence of amyloid-β (Aβ) peptides, which form amyloid plaques, and therefore, it is a primary target for treatment studies. Naturally occurring peptides have garnered attention for their potential pharmacological benefits, particularly in the central nervous system.

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Article Synopsis
  • TMPRSS2 is an accessory protease that increases the entry of SARS-CoV-2 into cells expressing ACE2, impacting how the virus interacts with host cells during infection.
  • Experiments showed that TMPRSS2 enhances the internalization of the virus, improves early replication rates, and modifies immune responses, depending on the virus variant.
  • The study reveals that TMPRSS2 not only affects viral uptake and replication but also leads to increased cell death and drives the evolution of viral mutations, linking these processes to the effectiveness of the host's immune response.
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Oropouche virus (OROV) is a member of the family and the causative agent of a dengue-like febrile illness transmitted by mosquitoes. Although mild symptoms generally occur, complications such as encephalitis and meningitis may develop. A lack of proper diagnosis, makes it a potential candidate for new epidemics and outbreaks like other known arboviruses such as Dengue, Yellow Fever and Zika virus.

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The arbovirus Chikungunya (CHIKV) is transmitted by mosquitoes in urban environments, and in humans, it triggers debilitating symptoms involving long-term complications, including arthritis and Guillain-Barré syndrome. The development of antiviral therapies is relevant, as no efficacious vaccine or drug has yet been approved for clinical application. As a detailed map of molecules underlying the viral infection can be obtained from the metabolome, we validated the metabolic signatures of Vero E6 cells prior to infection (CC), following CHIKV infection (CV) and also upon the inclusion of the nsP2 protease inhibitor wedelolactone (CWV), a coumestan which inhibits viral replication processes.

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