Publications by authors named "R C Dodel"
To investigate the outcomes of geriatric COVID-19 patients in a German academic setting during the pandemic. This study included 468 consecutive geriatric patients (≥ 70 years) who tested positive for SARS-CoV-2 and were treated at the University of Duisburg-Essen from 2/2020 to 3/2021. 74 patients were transferred to a geriatric hospital and a 12-month follow-up (prospective study) was performed in 51 patients.
View Article and Find Full Text PDFIntroduction And Methods: Aiming to evaluate safety aspects of a recently proposed approach to target Alzheimer's disease, we mimicked a complex boron neutron capture therapy field using a mixed beam consisting of high- and low-linear energy transfer (LET) radiation, Am alpha particles (α) and/or X-ray radiation respectively, in human microglial (HMC3) cells.
Results: Acute exposure to 2 Gy X-rays induced the strongest response in the formation of γH2AX foci 30 min post irradiation, while α- and mixed beam-induced damage (α:X-ray = 3:1) sustained longer. Fractionation of the same total dose (0.
Article Synopsis
- Alzheimer's (AD) and Parkinson’s disease (PD) are major neurodegenerative disorders characterized by specific protein aggregations, with Alzheimer’s linked to amyloid-beta (Aβ) and tau, and Parkinson’s associated with alpha-synuclein (αSyn).
- The research examined naturally occurring autoantibodies (nAbs), including IgG, IgM, and IgA, in patients with AD, PD, and dementia with Lewy bodies (DLB), revealing altered levels and affinities of these antibodies compared to healthy controls.
- Findings indicated that AD patients had lower high-affinity anti-αSyn and anti-Aβ IgGs, while DLB patients showed increased anti-αSyn IgG but decreased Ig
Background: Recent studies have described higher incidences of concussion, with more severe symptoms and worse outcomes in female athletes compared with male athletes.
Purpose: To compile current knowledge about sex-specific differences in incidence, biomechanics, biomarkers, imaging, and outcomes of concussion in athletes participating in contact sports to better understand which fields should be explored in more detail.
Study Design: Scoping review; Level of evidence, 3.