Publications by authors named "R C D'Arcy"
Introduction: Cognitive deficits are common in psychiatric and mental health disorders, making the assessment of cognitive function in mental health treatment an important area of research. Cognitive Function Development Therapy (CFDT) is a novel therapeutic modality designed to enhance cognitive function and regulate the autonomic nervous system through targeted exercises and activities focused on attention networks and memory systems. The therapy is tracked and based on Primary Cognitive Function (PCF) scores.
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- Recent brain studies indicate that athletes in contact sports experience measurable cognitive and sensory impairments due to cumulative subconcussive impacts throughout the season.
- This study compares a high-contact group to a low-contact control group and includes both male and female high school athletes, using 231 brain scans over a year.
- Results show that while both genders exhibit similar subconcussive impairments, female athletes respond more significantly overall, indicating the importance of monitoring these changes to improve health outcomes related to repetitive head impacts.
Article Synopsis
- siRNA therapeutics have great potential for treating cancer, but effective delivery methods that reduce toxicity while promoting rapid cellular uptake have been difficult to develop.
- Our team created an innovative siRNA conjugate platform named "siRNA-L," which uses natural albumin in the bloodstream for targeted delivery to tumors without relying on traditional lipid or polymer methods.
- To enhance the effectiveness of siRNA-L, we synthesized a new conjugate called siRNA-CQ-L that incorporates chloroquine for better endosomal escape and higher gene silencing efficiency, showing no significant toxicity in mice while improving delivery and retention in cancer cells.
Article Synopsis
- The study examined brain vital signs, specifically event-related potentials (ERPs), in mixed martial arts (MMA) athletes compared to non-athlete controls to see if head impacts affect brain function.
- Using established ERPs like N100, P300, and N400, the research aimed to identify differences in cognitive processing and attention between the two groups.
- Results showed significant reductions in N400 amplitudes for MMA athletes, suggesting that repeated head impacts could alter brain function and cognitive processing.