Publications by authors named "R C Costello"
Background: Imatinib is the treatment of elderly or frail patients with chronic myeloid leukemia (CML). Trough levels of around 1000 ng/ml are considered as the target exposure.
Objectives: We searched for baseline parameters associated with imatinib pharmacokinetics, and studied the clinical impact of subsequent adaptive dosing.
Article Synopsis
- * These technologies pave the way for decentralized clinical trials, allowing for a more inclusive study population, reduced costs, and faster access to new treatments.
- * The discussion includes the use of digital endpoints, different trial designs, a specific example of a fully decentralized asthma trial, and examines the pros and cons of these methods from various perspectives (clinicians, patients, and regulators).
Featuring scientists in classroom materials provides opportunities for students to relate to scientists as role models and see themselves in science. However, it is unclear what information students find most relatable when encountering scientists throughout their education. In this study, we manipulated the amount and type of information provided about scientists featured in biology courses.
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- Researchers investigated whether ursodeoxycholic acid (UDCA), used for cholestatic liver diseases, could lower the risk of severe COVID-19 outcomes in patients with primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC).
- In a population-based study, data from over 11,000 individuals was analyzed, revealing that UDCA users had a 21% lower risk of hospitalization or death from COVID-19 compared to non-users.
- The findings warrant further clinical trials to explore UDCA's potential as a preventive treatment for severe COVID-19 outcomes.
Population age structure shapes selection on social behaviour in a long-lived insect.
Philos Trans R Soc Lond B Biol Sci
December 2024
Social traits are expected to experience highly context-dependent selection, but we know little about the contextual factors that shape selection on social behaviours. We hypothesized that the fitness consequences of social interactions will depend on the age of social partners, and therefore that population age structure will shape evolutionary pressures on sociality. Here, we investigate the consequences of age variation at multiple levels of social organization for both individual fitness and sexual selection on social network traits.
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