Publications by authors named "R C Cook"
Background: There is minimal literature on the outcomes of acute traumatic subdural hematoma (SDH) in patients 90 years of age or older. This study aims to characterize the presentation and acute outcomes of patients in this population, particularly for surgical candidates.
Methods: Patients 90 years of age or older with acute SDH between 2013-2023 were analyzed (n = 117).
The anti-apoptotic protein myeloid cell leukemia-1 (Mcl-1) contributes to the pathophysiology of acute myeloid leukemia (AML) and certain B-cell malignancies. Tumor dependence on Mcl-1 is associated with resistance to venetoclax. Voruciclib, an oral cyclin-dependent kinase (CDK) inhibitor targeting CDK9, indirectly decreases Mcl-1 protein expression and synergizes with venetoclax in preclinical models.
View Article and Find Full Text PDFArticle Synopsis
- Soil organic matter (SOM) is crucial for reducing greenhouse gas emissions and supporting global climate, carbon cycles, and biodiversity.
- Coastal wetland soils, which constitute one-third of SOM, are eroding rapidly due to rising sea levels, highlighting a gap in research on carbon sequestration in these areas compared to upland soils.
- Using solid-state nuclear magnetic resonance (ssNMR), the study reveals that some molecular structures in wetland soils have been preserved for over 1,000 years, but these structures are declining in abundance as decomposition and repolymerization processes occur, making coastal wetland SOM increasingly vulnerable to environmental changes.
Previous work suggests that HIV stigma is associated with greater pain severity. We sought to characterize this relationship by examining intersectional identities that tend to be stigmatized (i.e.
View Article and Find Full Text PDFEffect of Patient Resilience on Functional Outcomes After Meniscectomy.
Orthop J Sports Med
November 2024
Article Synopsis
- - The study investigated how preoperative patient resilience impacts outcomes two years after arthroscopic meniscectomy, particularly focusing on psychological factors affecting recovery.
- - 100 patients who underwent the surgery were analyzed, revealing that those with higher resilience had better initial knee function scores, but resilience levels changed post-surgery, with some patients' resilience improving and others' declining.
- - Ultimately, the findings suggested that although higher resilience correlates with better preoperative outcomes, it did not consistently predict differences in long-term patient-reported outcomes after surgery.