A portrait of germline pathogenic variants in high and moderate penetrance breast cancer genes in Brazil.

Introduction: The prevalence of germline pathogenic/likely pathogenic variants (P/LP) in high and moderate penetrance (HMP) genes is approximately 7%-10% among breast cancer (BC) patients. The prevalence and spectrum of BC P/LP variants are affected by several factors. There are limited genetic data from Brazilian patients with BC.

Erdheim-Chester Disease: A Case Report Exploring Multisystemic Involvement.

Erdheim-Chester disease (ECD) is a rare, multisystemic, non-Langerhans cell histiocytic neoplasm predominantly affecting middle-aged males in their fifth to seventh decades of life. It often presents with nonspecific symptoms, leading to a delay in its diagnosis. We report a case of an 85-year-old male with multisystemic manifestations, including retroperitoneal, skeletal, vascular, cardiac, orbital, and central nervous system (CNS) involvement.

NEW NON-MARINE OSTRACOD GENERA AND SPECIES OF APTIAN AGE FROM ARARIPE BASIN, NORTHEAST BRAZIL.

The Ostracoda Subclass comprises the most expressive group of calcareous microfossils in the deposits of the Araripe Basin, especially in its post-rift sequence, which is represented by the Santana Group, of Late Aptian age (= Alagoas Local Stage). Due to the abundance, ostracod species are of great importance for understanding the evolution of the Araripe Basin, with direct application in biostratigraphic and paleoecological analyses. Improving these important applications involves refining the taxonomy of these ostracods, which also contributes to understanding the diversity of this fauna.

Sexual function in female business leaders: a cross-sectional study.

Objective: The aim of the study was to provide a golden opportunity to access sexual function in women who act as leaders in companies through the use of an instrument validated for this purpose (the Female Sexual Function Index). The number of women in leadership positions has been gradually increasing, which shows the need for women to prepare themselves to reorganize the different aspects of life, including social, family, and personal factors as well as sexuality.

Methods: This is a cross-sectional study involving female executives employed in private companies who answered the Female Sexual Function Index.

Flank-free modified supine vs. prone position for pediatric nephrolithotripsy: an updated systematic review and meta-analysis.

Introduction: Percutaneous nephrolithotomy (PCNL) is widely performed as the preferred treatment for kidney stones larger than 20 mm in pediatric patients, with current research focusing on comparing outcomes between prone and supine positions to determine optimal procedural positioning. Therefore, the aim of this study is to compare the efficacy of prone versus supine positioning in pediatric PCNL, providing clarity on this critical aspect of the procedure to guide clinical decision-making.

Methods: We conducted a systematic review in PubMed, Embase, Scopus, Cochrane, Web of Science and Google Scholar.