Publications by authors named "R Buttazzi"
Use of Azithromycin Attributable to Acute SARS-CoV-2 Infection.
Pharmacoepidemiol Drug Saf
July 2024
Article Synopsis
- This study investigated the impact of early pandemic misinformation on the prescription rates of azithromycin for COVID-19 treatment, highlighting a gap in individual-level data linking the antibiotic's use to SARS-CoV-2 infection.
- The analysis covered a cohort of patients from February 2020 to February 2022 and used prescription data from Emilia-Romagna, Italy, to assess how azithromycin consumption changed during different COVID-19 virus variants.
- Results showed a significant increase in azithromycin usage during the acute phase of COVID-19 compared to control periods, but consumption levels returned to baseline once the acute phase passed, with only 12.9% of azithromycin use linked to COVID-19.
Background: Knowledge about the dynamics of transmission of SARS-CoV-2 and the clinical aspects of COVID-19 has steadily increased over time, although evidence of the determinants of disease severity and duration is still limited and mainly focused on older adult and fragile populations.
Methods: The present study was conceived and carried out in the Emilia-Romagna (E-R) and Veneto Regions, Italy, within the context of the EU's Horizon 2020 research project called ORCHESTRA (Connecting European Cohorts to increase common and effective response to SARS-CoV-2 pandemic) (www.orchestra-cohort.
Reduction trend of mcr-1 circulation in Emilia-Romagna Region, Italy.
Eur J Clin Microbiol Infect Dis
December 2021
This study aims to describe trends of mcr-positive Enterobacterales in humans based on laboratory surveillance with a defined catchment population. The data source is the Micro-RER surveillance system, established in Emilia-Romagna region (Italy), to monitor the trend of mcr resistance. Enterobacterales isolates from human clinical samples with minimum inhibitory concentration (MIC) ≥ 2 mg/L for colistin were sent to the study reference laboratory for the detection of mcr genes.
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- Antibiotic prescriptions for children with acute otitis media and sore throat in Emilia-Romagna decreased significantly (37% from 2005 to 2019) after implementing evidence-based guidelines from the ProBA project.
- The study investigated whether this reduction in antibiotic use led to an increase in complications such as acute mastoiditis and acute rheumatic fever, finding that rates of mastoiditis and surgical treatments declined, while ARF rates remained stable.
- The findings support the ProBA project's approach to treating AOM and streptococcal pharyngitis with recommended durations of amoxicillin, showing that less antibiotic use did not result in increased complications.