Publications by authors named "R Burla"
Telomeres are pivotal determinants of cell stemness, organismal aging, and lifespan. Herein, we examined similarities in telomeres of Arabidopsis thaliana, mice, and humans. We report the common traits, which include their composition in multimers of TTAGGG sequences and their protection by specialized proteins.
View Article and Find Full Text PDFThe endosomal sorting complex required for transport (ESCRT) machinery is composed of an articulated architecture of proteins that assemble at multiple cellular sites. The ESCRT machinery is involved in pathways that are pivotal for the physiology of the cell, including vesicle transport, cell division, and membrane repair. The subunits of the ESCRT I complex are mainly responsible for anchoring the machinery to the action site.
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- DNA damage is identified as a significant contributor to heart disease, particularly involving cardiomyocytes and smooth muscle cells, though the details are not fully understood.
- Research focused on a factor called Ft1 in mice and AKTIP in humans, revealing that its depletion leads to telomere instability and DNA damage, impacting heart health.
- Two mouse models with varying Ft1 depletion showed that both developed cardiac issues like hypertrophy and fibrosis, but the smooth muscle-targeted model exhibited milder, age-exacerbated symptoms, suggesting Ft1 deficiency is a key factor in cardiac disease progression.
Background: Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but their accuracy is still debated. AKTIP is a telomeric protein with the property of being enriched at the nuclear lamina. AKTIP has similarity with the tumor susceptibility gene TSG101.
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