Investigation of accelerated partial breast patient alignment and treatment with helical tomotherapy unit.

Purpose: To determine the precision of megavoltage computed tomography (MVCT)-based alignment of the seroma cavity for patients undergoing partial breast irradiation; and to determine whether accelerated partial breast irradiation (APBI) plans can be generated for TomoTherapy deliveries that meet the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-39/Radiation Therapy Oncology Group (RTOG) 0413 protocol guidelines for target coverage and normal tissue dose limitations.

Methods And Materials: We obtained 50 MVCT images from 10 patients. An interuser study was designed to assess the alignment precision.