Publications by authors named "R Buhl"
Background: Clinical studies of biologics in severe asthma exclude smokers or ex-smokers (ExS) with over 10 pack-years (py). Thus, the effectiveness of this therapy in ex-smokers with severe asthma is not well understood.
Objectives: To assess the impact of smoking on clinical efficiency of biologics in patients with severe asthma from the German Asthma Net (GAN), a comprehensive international registry.
Article Synopsis
- * Interleukin-5 (IL-5) is crucial in the activation and survival of eosinophils, making it an essential target for treatments aimed at severe asthma, with therapies like mepolizumab and reslizumab blocking IL-5, while benralizumab targets its receptor for enhanced efficacy.
- * Despite the lack of direct comparative trials for these therapies, research continues to explore the differences between partial and complete eosinophil depletion, highlighting the ongoing debate about their clinical significance in treating eosinophilic asthma. *
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Faster lung function impairment occurs earlier in the disease, particularly in mild-to-moderate COPD, highlighting the need for early and effective targeted interventions. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2024 report recommends initial pharmacologic treatment with a long-acting muscarinic antagonist (LAMA) and long-acting β-agonist (LABA) combination in group B (0 or 1 moderate exacerbation not leading to hospitalization, modified Medical Research Council score of ⩾2, and COPD Assessment Test™ score of ⩾10) and E (⩾2 moderate exacerbations or ⩾1 exacerbation leading to hospitalization and blood eosinophil count <300 cells/µL) patients.
View Article and Find Full Text PDFIntroduction: Lung cancer is the malignancy with the highest mortality rate worldwide. In January 2025, the German public healthcare system will introduce a new regulation according to which a centre can offer surgery for lung cancer only if it carries out a minimum number of lung resections. The purpose of this directive is to reduce the number of centres offering surgical treatment for primary lung cancer, thus centralising and improving lung cancer care.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between phosphate levels in aqueous humor and the risk of calcification in intraocular lenses (IOLs), especially in diabetic patients.
- In vitro tests involved different IOL models exposed to varying phosphate concentrations to assess calcification using several analytical methods.
- Results indicated that higher phosphate concentrations and longer exposure times significantly increased the risk of IOL calcification, supporting the hypothesis that diabetic conditions may elevate this risk.