Publications by authors named "R Buffa"
Background: The demand for healthcare services during the COVID-19 pandemic was excessive for less-resourced settings, with intensive care units (ICUs) taking the heaviest toll.
Objective: The aim was to achieve adequate personal protective equipment (PPE) use in 90% of patient encounters, to reach 90% compliance with objectives of patient flow (OPF) and to provide emotional support tools to 90% of healthcare workers (HCWs).
Methods: We conducted a quasi-experimental study with an interrupted time-series design in 14 ICUs in Argentina.
Hyaluronan, a linear glycosaminoglycan comprising D-N-acetylglucosamine and D-glucuronic acid, is the main component of the extracellular matrix. Its influence on cell proliferation, migration, inflammation, signalling, and other functions, depends heavily on its molecular weight and chemical modification. Unsaturated HA oligosaccharides are available in defined length and purity.
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- Researchers have developed a new process to reduce negatively charged glucuronate units in hyaluronic acid (HA) to less polar glucose units, potentially altering its properties.
- This one-pot method effectively converts HA to a derivative (HA-Red) with carboxyl groups turned into primary alcohols while maintaining the integrity of the polymer, achieving molecular weights up to 1000 kDa.
- Preliminary studies indicated that HA-Red shows greater stability when exposed to heat or an enzyme that typically degrades HA, and it does not harm the growth of fibroblast cells, making it a promising option for biodegradable and biocompatible applications.
Background: Bioelectrical impedance analysis (BIA) is a technique widely used for estimating body composition and health-related parameters. The technology is relatively simple, quick, and non-invasive, and is currently used globally in diverse settings, including private clinicians' offices, sports and health clubs, and hospitals, and across a spectrum of age, body weight, and disease states. BIA parameters can be used to estimate body composition (fat, fat-free mass, total-body water and its compartments).
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