Hyalinizing spindle cell tumor with giant rosettes of the hand. A surgical and histopathological rarity.

Hyalinizing spindle cell tumor with giant rosettes is a recently described biphasic neoplasm of soft tissue that shares mesenchymal and neuroendocrine features. The tumors have quite distinctive histopathological features with the presence of hyalinized paucicellular foci that are defined as rosettes. Only a few cases of this rare tumor have been described so far.

Differential stripping demonstrates a significant reduction of the hair follicle reservoir in vitro compared to in vivo.

Penetration studies are commonly performed on in vitro models, presumably due to a lack of non-invasive in vivo methods. To date, it is not clear whether in vitro models are suitable to reflect the in vivo conditions for percutaneous penetration. Apart from inter and intraspecies skin differences, the excision of a skin sample may influence the penetration rate inter alia as a result of the contraction of the elastic fibres in the skin during excision.

Squamous cell carcinoma arising on a skin graft 64 years after primary injury.

Malignant degeneration of a chronic wound is often described by the term, Marjolin's ulcer. We present a case of a squamous cell carcinoma that developed in a patient 64 years after the initial injury during World War II. Tissue contusion and detachment required repeated surgery and full skin grafting in several hospitals.