Publications by authors named "R Buda"
Knee osteoarthritis (KOA) is a chronic degenerative disease characterized by progressive joint damage leading to significant disability. Although rehabilitative treatment methods for KOA have been widely implemented, the optimal integrated instrumental physical therapy approach remains unclear. Therefore, this study aimed to analyze the effect of Quantum Molecular Resonance (QMR) on pain reduction as the primary outcome and the functional improvement in activity daily living (ADL) as a secondary outcome.
View Article and Find Full Text PDFBackground: The purpose of this study was to assess the long-term clinical efficacy of first-generation autologous chondrocyte implantation (ACI) technique for osteochondral lesions of the ankle joint.
Methods: Eleven patients with symptomatic OLTs underwent ACI from December 1997 to October 2002. A total of 9 patients (5 men, 4 women, age 25.
Sex does not influence the long-term outcome of matrix-assisted autologous chondrocyte transplantation.
Knee Surg Sports Traumatol Arthrosc
October 2024
Article Synopsis
- This study explores the long-term effects of sex on the clinical outcomes of regenerative procedures for knee cartilage repairs using matrix-assisted autologous chondrocyte transplantation (MACT) in 235 patients, with a follow-up averaging 14 years.
- Results show that men had a significantly lower failure rate (10.7%) compared to women (28.8%) and higher overall knee function scores, but when comparing matched groups of men and women, outcomes were similar.
- The research highlights that women tend to have more complex lesion patterns, making their recovery from knee cartilage repair more challenging despite both sexes experiencing improvements over time.
This study aimed to investigate the anti-inflammatory effects of Quantum Molecular Resonance (QMR) technology in an in vitro model of osteoarthritis-related inflammation. The study used THP-1-derived macrophages stimulated with lipopolysaccharide and hyaluronic acid fragments to induce the expression of inflammatory cytokines and nitrosative stress. QMR treatment inhibited COX-2 and iNOS protein expression and activity and reduced NF-κB activity.
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