Publications by authors named "R Brzyski"
Background: Clomiphene is the current first-line infertility treatment in women with the polycystic ovary syndrome, but aromatase inhibitors, including letrozole, might result in better pregnancy outcomes.
Methods: In this double-blind, multicenter trial, we randomly assigned 750 women, in a 1:1 ratio, to receive letrozole or clomiphene for up to five treatment cycles, with visits to determine ovulation and pregnancy, followed by tracking of pregnancies. The polycystic ovary syndrome was defined according to modified Rotterdam criteria (anovulation with either hyperandrogenism or polycystic ovaries).
Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied.
View Article and Find Full Text PDFObjective: To summarize baseline characteristics from a large multicenter infertility clinical trial.
Design: Cross-sectional baseline data from a double-blind randomized trial of two treatment regimens (letrozole vs. clomiphene).
Objective: The aim of this study was to determine whether a dietary intervention designed to reduce fat intake and increase intake of fruit, vegetables, and whole grains, and weight loss, reduces vasomotor symptoms (VMS; ie, hot flashes or night sweats) in postmenopausal women.
Methods: We included 17,473 postmenopausal US women, ages 50 to 79 years, at baseline who participated in the Women's Health Initiative Dietary Modification trial and were not taking menopausal hormone therapy. Logistic regression was used to evaluate associations.
Article Synopsis
- The study aimed to see if shedding the endometrial lining induced by progestin affects ovulation, conception, and live birth rates in women with PCOS before receiving fertility treatments.
- Analysis of data from 626 women revealed that while ovulation rates were higher following spontaneous bleeding, the actual conception and live birth rates were significantly lower after any induced shedding compared to cycles without it.
- The research suggests that the common practice of using progestin to induce bleeding before treatment may have a negative impact on conception and live birth rates in women with PCOS.