Publications by authors named "R Breathnach"
Article Synopsis
- Canine demodicosis is a common skin disease caused by an overgrowth of Demodex mites, with complex factors like T-cell exhaustion and immune responses potentially playing a role in its development.
- The study employed mass spectrometry and pathway analysis to reveal that endoplasmic reticulum (ER) stress activates signaling pathways linked to immune regulation, particularly affecting Toll-like receptors and promoting M2 macrophage development.
- Findings demonstrated that the interaction between Demodex mites and the immune system creates an immunosuppressive environment that facilitates the mites' proliferation, highlighting significant molecular changes in affected dogs.
Article Synopsis
- Canine demodicosis is a skin condition in dogs caused by an overgrowth of Demodex mites, often linked to immune-related issues like diseases or immunosuppressive treatments.
- The study examines skin gene expression in affected dogs using a gene panel, revealing an increase in certain types of T cells (Th1 and Treg) in those with demodicosis compared to healthy controls.
- Results indicate that the presence of Demodex mites may help them evade the dog's immune system by increasing immunosuppressive cytokines and immune checkpoint molecules, promoting an immune-tolerant environment.
Canine demodicosis, due to an overpopulation of Demodex spp. mites, remains one of the most common dermatological diseases encountered in small animal practice. The aims of this study were to interrogate submitted histories and diagnostic report results from a large cohort of dogs (n = 508) diagnosed with demodicosis either through histological analysis or the finding of Demodex spp.
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