Publications by authors named "R Bova"
Article Synopsis
- - IAIs (intra-abdominal infections) are a leading cause of serious illness and death, especially in sepsis cases, with high hospital mortality rates (23-38%); timely identification and treatment are essential for better outcomes.
- - Effective management involves source control, which includes various procedures such as surgery, drainage, and debridement to remove the infection source and restore function, alongside early clinical evaluation and the use of prognostic scores to assess severity.
- - Rising antibiotic resistance poses a major global health challenge, highlighting the importance of appropriate antibiotic use, infection control measures, and adherence to guidelines in surgical departments to improve patient outcomes.
Objectives: Myocardial ischaemia following coronary artery bypass grafting (CABG) is a potentially devastating complication. Nevertheless, the incidence, aetiology and prognostic relevance of unplanned coronary angiography (uCAG) remain understudied. We aimed to investigate the prevalence and outcome of patients undergoing urgent, uCAG in the postoperative period following CABG.
View Article and Find Full Text PDFIn the past few years NGS has become the technology of choice to replace animal-based virus safety methods and this has been strengthened by the recent revision to the ICHQ5A virus safety chapter. Here we describe the validation of an NGS method using an agnostic analysis to detect and identify RNA virus and actively replicating DNA virus contaminants in cell banks. We report the results of the validation of each step in the sequencing process that established quality criteria to ensure consistent sequencing data.
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- Non-operative management (NOM) for uncomplicated acute appendicitis is a viable alternative to surgery, with this study comparing outpatient (outNOM) and inpatient (inNOM) approaches.
- The study involved 668 patients, showing that outNOM was non-inferior to inNOM in terms of the rate of appendectomies within 30 days and had a shorter average hospital stay (0.89 days vs. 3.94 days).
- Though some outNOM patients visited the emergency department unexpectedly, overall safety and effectiveness of outpatient NOM were supported, indicating a need for further research.
Shiga toxins (Stxs) produced by ingested can induce hemolytic uremic syndrome after crossing the intact intestinal barrier, entering the bloodstream, and targeting endothelial cells in the kidney. The method(s) by which the toxins reach the bloodstream are not fully defined. Here, we used two polarized cell models to evaluate Stx translocation: (i) a single-layer primary colonic epithelial cell model and (ii) a three-cell-layer model with colonic epithelial cells, myofibroblasts, and colonic endothelial cells.
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