[The cannabis pandemic: why use this expression? Epidemiology].

Using the term of pandemic to characterize the current use of cannabis is fully warranted considering the results of recent surveys [Halte au cannabis. Paris: Odile Jacob; 2006]. A pandemic is defined as an epidemic affecting populations in a very wide geographical zone which may involve one or several continents.

[Illicit drugs, medications and traffic accidents].

The European Union (EU) has 25 member-states and 455 million inhabitants. Statistics on traffic accidents in the EU show that more than 45,000 people are killed annually, including 5200 in France. At the same time, nearly two million persons in the EU require medical treatment for traffic-accident-related injuries, including 109,000 in France.

[Pharmacology, an innovative factor in therapeutic research].

As members of the pharmacology training group set up by the committee of pharmacological science of the French Academy of Pharmacy, we examine the situation of pharmacology in drug discovery. Today, it is obvious that by integrating genome sequencing, cellular and molecular biology, and bioinformatics, pharmacology has become a cross-disciplinary science. Pharmacologists must become knowledgeable in a wide range of domains, using the major points in each to direct them towards the discovery and development of new therapeutic agents.

Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat.

Traumatic brain injury produces nitric oxide and reactive oxygen species. Peroxynitrite, resulting from the combination of nitric oxide and superoxide anions, triggers DNA strand breaks, leading to the activation of poly(ADP-ribose)polymerase-1. As excessive activation of this enzyme induces cell death, we examined the production of nitrosative stress, the activation of poly(ADP-ribose)polymerase-1, and the role of this enzyme in the outcomes of traumatic brain injury produced by fluid percussion in rats.