Publications by authors named "R Boukari"
Purpose: In this study, we retrospectively reviewed the use of flow cytometry (FCM) in the diagnosis of inborn errors of immunity (IEIs) at a single center in Algeria. Sharing insights into our practical experience, we present FCM based diagnostic approaches adapted to different clinical scenarios.
Methods: Between May 2017 and February 2024, pediatric and adult patients presenting with clinical features suggestive of immunodeficiency were subjected to FCM evaluation, including lymphocyte subset analysis, detection of specific surface or intracellular proteins, and functional analysis of immune cells.
Article Synopsis
- - Kawasaki disease (KD) is the leading cause of acquired heart disease in children from developed countries, necessitating detailed studies within Arab nations to enhance diagnosis and care.
- - Kawarabi is a collaborative initiative involving North American and Arab experts aimed at improving knowledge and management of KD and similar conditions, primarily initiated during the COVID-19 pandemic's emergence of multisystem inflammatory syndrome in children.
- - Founded in 2021, Kawarabi has identified gaps in awareness and resources concerning KD in Arab countries, and it has organized educational webinars and meetings to promote better understanding of the disease and its long-term outcomes.
Article Synopsis
- - Kawasaki Disease (KD) remains the leading acquired heart disease in children under five, with limited data available from Arab nations, prompting the creation of the KD Arab Initiative (Kawarabi) in 2021 to enhance research and access to care.
- - A survey conducted across thirteen Arab countries revealed that while access to KD care was generally equal in urban and rural areas for over half of the countries surveyed, many rural areas still experienced significant disparities in healthcare access, especially in mid-size cities.
- - The survey indicated a difference in the quality of medical services for KD, with urban children receiving better care, and highlighted that the availability of intravenous immunoglobulin (IVIG) was critically low in rural and mid-size areas,
Human inborn errors of immunity (IEI) are a group of 485 distinct genetic disorders affecting children and adults. Signs and symptoms of IEI are heterogeneous, and accurate diagnosis can be challenging and depends on the available human expertise and laboratory resources. The Middle East and North Africa (MENA) region has an increased prevalence of IEI because of the high rate of consanguinity with a predominance of autosomal recessive disorders.
View Article and Find Full Text PDFMonogenic immune dysregulation diseases (MIDD) are caused by defective immunotolerance. This study was designed to increase knowledge on the prevalence and spectrum of MIDDs, genetic patterns, and outcomes in Middle East and North Africa (MENA). MIDD patients from 11 MENA countries (Iran, Turkey, Kuwait, Oman, Algeria, Egypt, United Arab Emirates, Tunisia, Jordan, Qatar, and Azerbaijan) were retrospectively evaluated.
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