Publications by authors named "R Bottino"
Human endocrine cell differentiation and islet morphogenesis play critical roles in determining islet cell mass and function, but the events and timeline of these processes are incompletely defined. To better understand early human islet cell development and maturation, we collected 115 pediatric pancreata and mapped morphological and spatiotemporal changes from birth through the first ten years of life. Using quantitative analyses and a combination of complementary tissue imaging approaches, including confocal microscopy and whole-slide imaging, we developed an integrated model for endocrine cell formation and islet architecture, including endocrine cell type heterogeneity and abundance, endocrine cell proliferation, and islet vascularization and innervation.
View Article and Find Full Text PDFAims: To assess the presence and the extent of an "aortic remodeling" in elite athletes.
Methods: A systematic review and meta-analysis of literature were conducted for studies (1981-2024) reporting echocardiographic aortic diameters of elite athletes compared to non-athlete healthy controls. Among the 5,494 studies retrieved, 21 (9,464 elite athletes vs.
Article Synopsis
- Unicuspid aortic valve (UAV) is a rare heart condition commonly confused with the more common bicuspid aortic valve (BAV), affecting young adults primarily around 36 years old.
- This study involved a systematic review and meta-analysis of 2953 studies, focusing on the demographic and clinical characteristics of UAV, which often includes associations with conditions like aortic coarctation and Turner syndrome.
- Surgical intervention, primarily aortic valve replacement (AVR), showed high survival rates (95-98%) over ten years, highlighting the need for further research into UAV as a distinct condition apart from BAV.
Article Synopsis
- This study investigates the effectiveness of two surfactant administration methods—INtubate-RECruit-SURfactant-Extubate (IN-REC-SUR-E) and less invasive surfactant administration (LISA)—on improving BPD-free survival in preterm infants with respiratory distress syndrome (RDS).
- A total of 382 preterm infants, born at 24-27 weeks' gestation and not intubated at birth, will be randomly assigned to either method within the first 24 hours of life. The primary outcome being measured is a combination of death or bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.
An estimated 1.5 million Americans suffer from Type I diabetes mellitus, and its incidence is increasing worldwide. Islet allotransplantation offers a treatment, but the availability of deceased human donor pancreases is limited.
View Article and Find Full Text PDF