-Heterocyclic Carbene Ligand Stability on Gold Nanoparticles in Biological Media.

The ability to functionalize gold nanoparticle surfaces with target ligands is integral to developing effective nanosystems for biomedical applications, ranging from point-of-care diagnostic devices to site-specific cancer therapies. By forming strong covalent bonds with gold, thiol functionalities can easily link molecules of interest to nanoparticle surfaces. Unfortunately, thiols are inherently prone to oxidative degradation in many biologically relevant conditions, which limits their broader use as surface ligands in commercial assays.

Imidazolinium -Heterocyclic Carbene Ligands for Enhanced Stability on Gold Surfaces.

-heterocyclic carbenes (NHCs) have emerged as versatile and robust ligands for noble metal surface modifications due to their ability to form compact, self-assembled monolayers. Despite a growing body of research, previous NHC surface modification schemes have employed just two structural motifs: the benzimidazolium NHC and the imidazolium NHC. However, different NHC moieties, including saturated NHCs, are often more effective in homogenous catalysis chemistry than these aforementioned motifs and may impart numerous advantages to NHC surfaces, such as increased stability and access to chiral groups.

Adenomyoma associated with high level of CA 125 and CA 19-9: case report.

Purpose Of Investigation: A rare case of increasing CA 125 and CA 19-9 levels increasing in a woman with adenomyoma is described.

Methods: A 39-year-old nullipara woman with CA 125 = 1,796 U/ml and CA 19-9 = 177 U/ml was submitted to abdominal and pelvic MRI, gastric endoscopy, colonoscopy, hysteroscopy, pelvic Doppler and PET scan. None of the exams revealed any apparent malignant disease.

[Culicidae (Diptera) in the dam area bordering the states of Santa Catarina and Rio Grande do Sul, Brazil].

The Culicidae composition of the Barra Grande Lake situated between the municipalities of Esmeralda (Rio Grande do Sul State) and Anita Garibaldi (Santa Catarina State) was assessed by monthly samplings. Twenty-four species were identified from a total of 1,185 specimens (74.7% as adults and 25.

Genic expression of the uterine leiomyoma in reproductive-aged women after treatment with goserelin.

Objective: To identify the genes presenting different expression in uterine leiomyomas after goserelin treatment.

Design: Retrospective analyses of tissue obtained in a prospective clinical study.

Setting: School of Medicine of the University of São Paulo.