Clustering the Brain With "CluB": A New Toolbox for Quantitative Meta-Analysis of Neuroimaging Data.

In this paper we describe and validate a new coordinate-based method for meta-analysis of neuroimaging data based on an optimized hierarchical clustering algorithm: CluB (Clustering the Brain). The CluB toolbox permits both to extract a set of spatially coherent clusters of activations from a database of stereotactic coordinates, and to explore each single cluster of activation for its composition according to the cognitive dimensions of interest. This last step, called "cluster composition analysis," permits to explore neurocognitive effects by adopting a factorial-design logic and by testing the working hypotheses using either asymptotic tests, or exact tests either in a classic inference, or in a Bayesian-like context.

Modelling the distribution of health-related quality of life of advanced melanoma patients in a longitudinal multi-centre clinical trial using M-quantile random effects regression.

Health-related quality of life assessment is important in the clinical evaluation of patients with metastatic disease that may offer useful information in understanding the clinical effectiveness of a treatment. To assess if a set of explicative variables impacts on the health-related quality of life, regression models are routinely adopted. However, the interest of researchers may be focussed on modelling other parts (e.

Occurrence of volatile organic compounds in shallow alluvial aquifers of a Mediterranean region: Baseline scenario and ecological implications.

A regional survey of eight volatile organic compounds (VOCs), namely BTEX (benzene, toluene, ethylbenzene and p-xylene) and four chlorinated aliphatic hydrocarbons (CAHs: chloroform, 1,2-dichloroethane, trichloroethene and tetrachloroethene), was carried out at 174 sites, in 17 alluvial aquifers of Abruzzo, a Mediterranean region of southern Italy, from 2004 to 2009. Frequency of detection, concentration range, spatial distribution pattern, and temporal trend of contaminant concentration in each aquifer were analyzed as well as the relationships between VOC concentrations and the total amount of precipitation during the 90days preceding each sampling date. A review of published ecotoxicological data, providing an indication of the biological risk associated with the observed levels of VOC contamination, was presented and discussed.

Adherence to medical treatment in inflammatory bowel disease patients.

Aim: Inflammatory bowel diseases (IBD) are a group of chronic intestinal conditions characterized by unpredictable course, with periods of flare-ups and remissions suggesting poor adherence to medical therapy. On the other hand adherence is one of the most common reason of failure in the treatment of chronic disease.

Methods: We have analyzed IBD patients' questionnaires, sent by IBD Society of Emilia-Romagna Region (Italy).

Endovenous laser ablation of great and small saphenous vein incompetence with a 1470-nm laser and radial fiber.

Objective: Endovenous laser ablation (EVLA) of great (GSV) and small saphenous vein (SSV) chronic insufficiency with 1470-nm diode laser and radial fiber yields good short-term results. The aim of this study was to assess its efficacy after at least 12 months of follow-up.

Methods: We performed a prospective interventional cohort study in an ambulatory care/day surgery setting.