Elexacaftor/tezacaftor/ivacaftor, a game-changer in cystic fibrosis: The Portuguese experience.

Background: Phase 3 trials of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) combination treatment in people with cystic fibrosis (CF) with ≥1 F508del-CFTR allele showed profound short-term effects on lung function, weight, and pulmonary exacerbations (PEx). The authors conducted a 12-month study to add evidence on the real-world long-term effectiveness and safety of CFTR modulator therapy with ELX/TEZ/IVA in Portuguese CF adult population.

Methods: Ambispective, multicentre, observational, real-life study involving all the Portuguese CF Reference Centres.

Arsenic and antimony desorption in water treatment processes: Scaling up challenges with emerging adsorbents.

The metalloids arsenic (As) and antimony (Sb) belong to the pnictogen group of the periodic table; they share many characteristics, including their toxic and carcinogenic properties; and rank as high-priority pollutants in the United States and the European Union. Adsorption is one of the most effective techniques for removing both elements and desorption, for further reuse, is a part of the process to make adsorption more sustainable and feasible. This review presents the current state of knowledge on arsenic and antimony desorption from exhausted adsorbents previously used in water treatment, that has been reported in the literature.

[The Impact of CFTR Modulating Therapy on Chronic Lung Infection in Patients with Cystic Fibrosis].

Cystic fibrosis is the most common lethal genetic disease in the white population, affecting approximately 80 000 people worldwide. It is an autosomal recessive, monogenic, and multisystemic disease, with over 2000 mutations described in the CFTR protein gene. The dysfunction of this protein leads to a decrease in the secretion of chlorine and bicarbonate, sodium hyperabsorption, and consequent water absorption, resulting in the thickening of secretions and accumulation of pathogens.

Anaerobic co-digestion of marine macroalgae waste and fruit waste: Effect of mixture ratio on biogas production.

Marine macroalgae waste (MMW) was used at different mixing ratios with fruit waste (FW) to evaluate the potential of co-digestion in enhancing methane yield. The process was conducted at mesophilic conditions (37 °C) with a fixed amount of biomass (10 g, 3.5% TS) and inoculum (150 mL; digested sewage sludge) and using MMW:FW ratios from 40:60 to 70:30.