COVID-19: using chest CT of major trauma patients to monitor and evaluate the second wave in London and the development of routine monitoring in practice.

Aim: To follow-up previous work evaluating incidental findings of COVID-19 signs on computed tomography (CT) images of major trauma patients to include the second wave prior to any major effects from vaccines.

Materials And Methods: The study population included all patients admitted following major trauma between 1 January 2020 and 28 February 2021 with CT including the lungs (n=1776). Major trauma patients admitted pre-COVID-19 from alternate months from January 2019 to November 2019 comprised a control group (n=837).

COVID-19: using chest CT of major trauma patients to monitor and evaluate the effect of lockdown and the importance of household size.

Aim: To use theory and practice to show how disease progression and regression can be described pre- and post-lockdown using an attack-sustain-decline-respite (ASDR) model and investigate how pre-lockdown disease prevalence and household size impacts on the effectiveness of lockdown.

Materials And Methods: Computed tomography (CT) scans from major trauma patients (considered as a random population sample) from the radiology department of St George's University Hospitals NHS Trust, London, have been used to explore COVID-19 disease at the population level.

Results: At lockdown on 23 March 2020 in the catchment area of St George's University Hospitals NHS Trust, an earlier paper showed that there was a high prevalence of disease of >20%.

COVID-19: could CT provide the best population level biomarker? Incidental COVID-19 in major trauma patients suggests higher than predicted rates of infection in London.

Aim: To evaluate incidental findings in major trauma patients, and to explore whether computed tomography (CT) could be used to assess prevalence and estimate disease spread in the general population.

Materials And Methods: The study population included all patients admitted following major trauma between 1 January 2020 and 30 April 2020 with CT including the lungs (n=523). Major trauma patients admitted pre-COVID-19 from 1-31 January and 1-31 March 2019 comprised a control group (n=252).

An analysis of screen-detected invasive cancers by grade in the English breast cancer screening programme: are we failing to detect sufficient small grade 3 cancers?

Objective: Randomised controlled trials have shown a reduction in breast cancer mortality from mammography screening and it is the detection of high-grade invasive cancers that is responsible for much of this effect. We determined the detection rates of invasive cancers by grade, size and type of screen and estimated relative sensitivities with emphasis on grade 3 detection.

Methods: This observational study analysed data from over 11 million screening episodes (67,681 invasive cancers) from the English NHS breast screening programme over seven screening years 2009/2010 to 2015/2016 for women aged 45-70.