Publications by authors named "R Blakytny"
Background: Septic shock remains associated with significant mortality rates. Arginine vasopressin (AVP) and analogs with V1A receptor agonist activity are increasingly used to treat fluid-resistant vasodilatory hypotension, including catecholamine-refractory septic shock. Clinical studies have been restricted to healthy volunteers and catecholamine-refractory septic shock patients excluding subjects with cardiac co-morbidities because of presumed safety issues.
View Article and Find Full Text PDFBackground: There is evidence that complement components regulate cytokine production in osteoblastic cells, induce cell migration in mesenchymal stem cells, and play a regulatory role in normal enchondral bone formation. We proved the hypothesis that complement might be involved in bone healing after fracture.
Methods: We investigated the expression of the key anaphylatoxin receptor C5aR during fracture healing in rats by immunostaining after 1, 3, 7, 14, and 28 days.
With the increasing worldwide prevalence of diabetes the resulting complications, their consequences and treatment will lead to a greater social and financial burden on society. One of the many organs to be affected is bone. Loss of bone is observed in type 1 diabetes, in extreme cases mirroring osteoporosis, thus a greater risk of fracture.
View Article and Find Full Text PDFBackground: Dynamization involves a reduction in fixation construct stiffness during bone healing, allowing increased interfragmentary movement of the fracture through physiologic weightbearing and muscle contraction. Within some optimal range, interfragmentary movement stimulates healing, but this range likely varies across stages of bone healing.
Questions/purposes: How does the time of dynamization affect the cartilage formation, bony bridging, and bone resorption in a rat fracture-healing model?
Methods: Unilateral external fixators, stabilizing a 1-mm gap, were dynamized at 1 (D1 group, n = 10), 3 (D3 group, n = 11), or 4 (D4 group, n = 11) weeks postoperatively.
Objectives: This study evaluated the effect of late dynamization on callus stiffness and size in a rat diaphyseal femoral osteotomy model. It was hypothesized that late dynamization, after bony bridging, would enhance healing.
Methods: The external unilateral fixator was dynamized by removal of the inner fixator bar at either 3 weeks (D3 group) or 4 weeks (D4 group) postoperation.