Publications by authors named "R Bino Kingsley"

Purpose: Native Americans (NAs) have the highest prevalence of diabetes mellitus (DM) of any racial group in the USA and are therefore at higher risk for diabetic retinopathy (DR) and diabetic macular edema (DME). This study estimated the prevalence of DR and DME among NAs receiving eye exams at the Citizen Potawatomi Nation (CPN) clinic, a tribal clinic in Oklahoma serving members of multiple tribes, and characterized risk markers associated with the presence and severity of DR.

Methods: A retrospective chart review identified tribal members with DM who received dilated retinal fundus exams at the CPN clinic between 2021 and 2023.

View Article and Find Full Text PDF
Article Synopsis
  • Alpha-1 adrenergic receptor (α1-AR) antagonists are drugs often used to treat benign prostatic hyperplasia and hypertension, but their potential link to cognitive impairment remains debated.
  • A systematic review was conducted to evaluate the association between these medications and cognitive dysfunction, analyzing 7 studies, primarily focusing on tamsulosin.
  • The findings suggested no strong causal relationship between α1-AR antagonists and cognitive issues, indicating these medications can be used without significant concern for affecting cognition.
View Article and Find Full Text PDF
Article Synopsis
  • Western diets can cause problems like liver diseases, and people are eating less protein from animals.
  • A study looked at how a low-protein diet (LPD) helps mice fight liver damage when they get infected with bacteria.
  • The findings showed that LPD reduces inflammation and helps the immune system work better by changing how immune cells behave in the liver.
View Article and Find Full Text PDF

The Enterobacteriaceae are a scientifically and medically important clade of bacteria, containing the model organism , as well as major human pathogens including and . Essential gene sets have been determined for several members of the Enterobacteriaceae, with the Keio single-gene deletion library often regarded as a gold standard. However, it remains unclear how gene essentiality varies between related strains and species.

View Article and Find Full Text PDF

Adhesins are crucial factors in the virulence of bacterial pathogens such as Escherichia coli. However, to date no resources have been dedicated to the detailed analysis of E. coli adhesins.

View Article and Find Full Text PDF